RefSeq Change Sift Pfam Go NM_021158 Q84R 1.00 0.0682648315585264 17.762776603 NM_002576 R237L 0.29 0.263241434774581 10.813902939 NM_002577 V414L 0.01 0.556302500767287 8.476552828 NM_006281 E303D 0.42 -0.138302698166281 13.530020079 NM_006282 R282K 1.00 0.0774122233087781 13.418113789 NM_006282 V312M 0.10 0.22606523401752 13.418113789 NM_003952 K196M 0.00 4.0321846833714 8.635025865 NM_004755 E151D 0.02 0.850237679666668 15.699638033 NM_003954 H674Y 1.00 0.154901959985743 7.676161412 NM_001274 R156Q 0.02 0.208715734345074 17.59367393 NM_001278 V268I 0.46 0.0377885608893997 12.593634163 NM_001278 V155A 0.99 0.332438459915605 12.593634163 NM_153361 L95I 0.75 0.261521454380307 6.810157213 NM_005990 C728G 0.01 0.0687158123694599 6.810157213 NM_005990 V408L 0.69 0.237360915794604 6.810157213 NM_020439 L110M 0.10 0.0347621062592119 9.10463735 NM_020439 V329I 0.19 0.133893579261226 9.10463735 NM_138995 K1082R 0.32 0.1249387366083 9.5552134 NM_138995 V770I 0.22 -0.0725506671486117 9.5552134 NM_138995 K309E 1.00 -0.118864588896107 9.5552134 NM_138995 I275V 1.00 0.859821296834963 9.5552134 NM_138995 E798K 0.12 1.39120662601307 9.5552134 NM_032237 I296V 1.00 0.0705810742857073 6.810157213 NM_001786 R59G 0.02 0.367126061257818 12.336755548 NM_001786 N288D 1.00 -0.00975983728915621 12.336755548 NM_004760 E286Q 0.30 0.0636690798693772 12.55210959 NM_004836 S727P 0.09 -0.00553248859996101 8.336096876 NM_004836 S136C 0.16 0.691001074664743 8.336096876 NM_004836 S704A 0.07 0.156347200859924 8.336096876 NM_017433 V369I 0.12 0.301029995663981 9.5552134 NM_017433 D204N 0.07 0.118099312077994 9.5552134 NM_017433 I348V 0.73 0.064117499611749 9.5552134 NM_017433 R319H 1.00 0.225779043244789 9.5552134 NM_017433 S956N 0.80 0.20012949992312 9.5552134 NM_006296 I167V 0.02 0.0930032896752475 7.353623771 NM_002082 L374F 0.05 1.66005193830565 7.813887602 NM_005204 S214F 0.00 1.92224034108717 8.207399712 NM_005204 A148T 0.39 0.176091259055681 8.207399712 NM_003600 G325W 0.00 3.37741834152744 14.75628912 NM_003600 I57V 1.00 -0.0170333392987803 14.75628912 NM_012424 D483V 0.25 0.149762320333332 8.476552828 NM_006875 K165R 0.00 3.49732464080795 10.57621648 NM_002731 L163I 1.00 0.120139853726531 10.214759479 NM_002731 H261N 0.33 -0.0430346322252018 10.214759479 NM_002731 H159N 0.00 3.74596656701224 10.214759479 NM_033115 K426N 0.48 -0.117113399096343 6.810157213 NM_003607 V1304I 0.63 0.034762106259212 10.361330481 NM_003607 R1198H 0.10 0.113943352306837 10.361330481 NM_003607 V1304L 1.00 0.113943352306837 10.361330481 NM_003607 D741N 0.13 0.139661993429006 10.361330481 NM_002732 F239L 0.00 1.25827801524303 9.356252215 NM_002732 H268D 1.00 -0.114954515701699 9.356252215 NM_033116 H429R 0.82 0.0564813559524482 8.866540499 NM_003390 C379R 0.00 2.41373427585527 11.470751349 NM_033118 G222R 0.84 0.237360915794604 7.676161412 NM_002737 I568V 0.07 0.104735350520013 12.505969343 NM_053006 C245S 0.13 1.93633092013062 9.184146922 NM_004196 L67P 0.00 2.04346569378109 11.470751349 NM_004196 Q275E 0.61 0.16840443038939 11.470751349 NM_002738 S563P 0.27 -0.42021640338319 8.206380016 NM_002738 S100I 0.39 0.0589778599593379 8.206380016 NM_007174 H845P 0.28 1.14266750356873 13.535770223 NM_006374 P76S 0.13 1.37161106994969 11.198016067 NM_006374 K374E 1.00 0.177645087124303 11.198016067 NM_001798 Y15S 0.00 0.638272163982407 17.278597118 NM_001798 V18L 0.00 2.41642341436605 17.278597118 NM_033550 T129A 0.58 0.111973759443932 10.280372262 NM_033550 L222M 0.08 0.301029995663981 10.280372262 NM_001799 Q130R 0.68 -0.037381727621332 23.212139484 NM_014397 P145A 0.29 0.451185520625263 10.418098452 NM_001291 A237V 0.07 0.439332693830262 9.414368063 NM_012290 D625V 0.00 0.278753600952829 17.070373747 NM_012290 N730Y 0.04 1.83884909073726 17.070373747 NM_012290 N730S 0.74 0.633468455579586 17.070373747 NM_002740 P560R 0.11 0.384576047114056 14.354916407 NM_002740 H508L 0.23 0.161850819941071 14.354916407 NM_002740 L485M 0.21 0.940002070324715 14.354916407 NM_002741 I718V 0.57 0.0398715120376923 9.761889037 NM_002741 V901I 0.14 0.342422680822206 9.761889037 NM_002742 Y598F 0.07 0.465583341325905 11.95124413 NM_002742 R877G 0.50 0.1249387366083 11.95124413 NM_002742 I596S 0.18 0.0347621062592119 11.95124413 NM_002742 R825K 0.23 -0.0791812460476249 11.95124413 NM_033126 Q132R 0.99 0.288795539246969 6.810157213 NM_033126 I336V 0.75 0.171682140150626 6.810157213 NM_033126 A176S 0.90 0.250620492186381 6.810157213 NM_002744 F451L 0.00 1.26626788940477 12.547684821 NM_002747 R371P 0.13 0.24491405368505 9.069879472 NM_002747 V38M 0.07 0.200359833782618 9.069879472 NM_002748 R256C 0.14 0.113943352306837 9.870270888 NM_002748 E254K 0.12 0.607455023214668 9.870270888 NM_007181 T204M 0.00 0.531478917042255 12.556381201 NM_007181 Q419H 0.11 0.138302698166281 12.556381201 NM_004850 T431N 0.63 0.372385904199649 9.076711118 NM_005228 G719C 0.00 2.88605664769316 19.161825136 NM_005228 R521K 0.91 0.0365168338257625 19.161825136 NM_005228 P266R 0.59 1.30930252162997 19.161825136 NM_005228 V592A 0.00 0.192690520875143 19.161825136 NM_005228 R962G 0.01 0.783683738983605 19.161825136 NM_005228 C624F 0.00 -0.059585689984244 19.161825136 NM_005228 R98Q 0.36 0.0649408069330145 19.161825136 NM_005228 V674I 0.11 0.46132698753643 19.161825136 NM_002752 N51S 0.11 0.160579092877434 9.972879102 NM_032409 H271Q 0.01 3.59542941242895 9.943030451 NM_032409 A340T 1.00 0.803705354856032 9.943030451 NM_032409 L347P 0.00 2.15358391805783 9.943030451 NM_032409 P305L 0.15 0.259637310505756 9.943030451 NM_032409 P209A 0.80 0.183644396946127 9.943030451 NM_002757 Q160L 0.05 0.143210032661026 7.610548629 NM_031464 P121L 0.01 0.15237698495524 6.810157213 NM_005734 S500N 0.10 0.500312917381596 14.718763416 NM_005734 V474I 1.00 0.0755007623092572 14.718763416 NM_005734 S740F 0.03 0.0563183630881206 14.718763416 NM_000075 R24C 0.01 0.348454645592119 11.442220679 NM_000075 R82Q 0.28 0.132907666279575 11.442220679 NM_007194 D347N 0.00 3.78440019966064 13.629742849 NM_007194 N446K 0.93 0.256826333171928 13.629742849 NM_007194 E501K 0.87 0.150492841080688 13.629742849 NM_007194 I448S 0.87 0.152090982651915 13.629742849 NM_007194 L512V 0.38 0.259637310505756 13.629742849 NM_007194 L436M 0.24 -0.0442036624920534 13.629742849 NM_007194 F447I 0.01 0.679664849140632 13.629742849 NM_007194 I157T 0.06 0.638272163982407 13.629742849 NM_007194 S500C 0.13 0.234813726780724 13.629742849 NM_007194 R117G 0.00 3.2373609157946 13.629742849 NM_032844 E167D 0.30 0.0511525224473813 6.810157213 NM_005160 V409M 0.10 0.0457574905606751 7.813887602 NM_013254 F45L 0.04 0.492915521902894 9.280618737 NM_013254 K570Q 0.03 0.208484788058375 9.280618737 NM_013254 N388D 0.61 0.0725506671486117 9.280618737 NM_005308 R304L 0.16 0.845098040014257 10.0771343 NM_005308 R304P 0.10 1.34242268082221 10.0771343 NM_005308 R304H 0.07 0.358431467388364 10.0771343 NM_005163 E319G 0.00 2.81291335664286 10.379690992 NM_005163 V167A 1.00 0.020203386088287 10.379690992 NM_005163 L357P 0.00 0.732393759822968 10.379690992 NM_003565 P478L 0.08 0.176091259055681 8.476552828 NM_001892 Q231K 0.00 0.596307662438871 7.610548629 NM_005813 Q546R 0.90 -0.138302698166281 7.840715684 NM_001895 M319L 0.25 -0.0364292656266749 8.476552828 NM_002401 A435G 0.39 -0.0713559085356683 8.679891801 NM_006549 R363C 0.00 1.01670569350285 11.590983784 NM_014496 H132P 0.02 3.27875360095283 8.861708887 NM_003137 I210T 0.00 1.06445798922692 14.903888156 NM_003137 R302K 0.82 0.259637310505756 14.903888156 NM_001396 Q123R 0.65 0.0492180226701816 11.53153252 NM_003718 L700R 1.00 0.0377885608893997 11.827376738 NM_003718 T671A 0.91 0.189056236220049 11.827376738 NM_003576 P236S 0.00 0.784682117542601 7.610548629 NM_006622 L677R 0.87 -0.6232492903979 8.679891801 NM_004954 H275P 0.25 0.205761929722901 13.161724681 NM_004954 P356Q 0.92 0.111973759443932 13.161724681 NM_004954 S357F 0.12 0.461609088541415 13.161724681 NM_001619 R211P 0.11 0.543319905522882 9.237958183 NM_001619 H422R 0.69 0.160296991872449 9.237958183 NM_001619 R211G 0.11 1.64206515299955 9.237958183 NM_005255 E816K 1.00 0.0184834056940131 12.479895277 NM_005255 I413V 0.23 0.0669467896306131 12.479895277 NM_003582 R313H 0.02 1.53926916146851 6.810157213 NM_003582 G396R 0.00 3.39794000867204 6.810157213 NM_003582 T351I 1.00 0.0538753807828546 6.810157213 NM_004384 K91E 0.00 0.660051938305649 7.610548629 NM_014720 T697I 0.28 0.0539818124662454 13.530397605 NM_014720 D117N 0.02 0.314602802853255 13.530397605 NM_014720 G666E 1.00 0.0969100130080563 13.530397605 NM_000314 D153H 0.09 0.08218675618735 12.079817823 NM_032294 A222D 0.64 -0.0540497612236248 10.280372262 NM_032294 E375G 0.38 0.552841968657781 10.280372262 NM_005906 D329E 0.95 0.0118992232997077 9.184146922 NM_014586 R591C 0.05 0.0442036624920535 8.861708887 NM_012119 K260R 0.29 -0.031257693730442 11.470751349 NM_012119 S86L 0.69 0.412180447786648 11.470751349 NM_012119 A137T 0.49 0.0457574905606751 11.470751349 NM_006201 P330L 0.00 3.63682209758717 8.866540499 NM_003157 N64D 0.06 2.68257958814785 11.470751349 NM_003157 A225P 1.00 -0.090176630349088 11.470751349 NM_003157 T357I 0.26 0.0404286570556082 11.470751349 NM_005406 Q1217E 1.00 -0.0377885608893997 12.852377105 NM_005406 L1097F 0.06 0.301029995663981 12.852377105 NM_005406 K222E 0.01 0.513923902627411 12.852377105 NM_144685 R302Q 0.13 0.0165992618194617 9.414368063 NM_006575 T633M 0.00 0.790050473683351 11.376295018 NM_006575 A334T 0.72 0.109144469425068 11.376295018 NM_005923 K950N 0.43 0.688985783429418 12.519741603 NM_145203 K225R 0.10 0.0908074140212025 7.610548629 NM_145203 E177K 0.01 0.0434656937810903 7.610548629 NM_145203 R170S 0.15 0.114821602316759 7.610548629 NM_145203 E42D 0.12 1.02928937610199 7.610548629 NM_016276 E136G 0.00 0.708310030590162 6.95814296 NM_003318 P789H 0.01 1.89085553057493 13.480694845 NM_003318 D758N 0.58 0.176091259055681 13.480694845 NM_002376 S456T 0.44 0.101457640758777 7.676161412 NM_002376 A516D 0.27 0.154901959985743 7.676161412 NM_002376 F410S 1.00 0.364699075533358 7.676161412 NM_015981 H219L 0.01 0.191068415025334 8.095493422 NM_015981 Q223K 0.39 0.0193051551953866 8.095493422 NM_001211 I909T 0.01 0.474574065705782 16.465965101 NM_001211 Q921H 0.33 0.0365168338257625 16.465965101 NM_001211 R814H 0.00 0.0969100130080563 16.465965101 NM_001211 R550Q 0.66 0.134698573897456 16.465965101 NM_001211 E409D 0.00 0.280826609575694 16.465965101 NM_001211 Q349R 0.35 0.0871501757189001 16.465965101 NM_001211 E390D 0.46 0.335447560467674 16.465965101 NM_001211 P378S 0.00 0.577926311611243 16.465965101 NM_001211 L1012P 0.00 0.183916596567638 16.465965101 NM_001211 L844F 0.02 -0.00454762775072068 16.465965101 NM_002953 S221F 0.00 0.79287450720435 7.610548629 NM_003684 P265L 0.00 3.61002892099924 7.444646778 NM_033266 S535T 0.56 0.223617772355203 10.632389517 NM_033266 V117I 0.60 0.204119982655925 10.632389517 NM_016281 N47S 0.73 0.469003364497483 7.610548629 NM_003688 D719Y 0.00 0.51634787812138 9.661585728 NM_014683 T533I 0.23 0.0969100130080565 6.810157213 NM_014683 M370V 0.33 0.353736346179984 6.810157213 NM_020168 P337L 0.03 0.107633878399829 6.810157213 NM_020168 H215R 0.42 0.2498774732166 6.810157213 NM_020168 P403R 0.00 -0.238882088915137 6.810157213 NM_020168 A14V 0.12 0.789146634685107 6.810157213 NM_017593 G405S 1.00 0.292429823902064 9.414368063 NM_017593 Q486H 0.03 0.0163904161881693 9.414368063 NM_017593 T342A 0.72 0.075421097174318 9.414368063 NM_014326 R57Q 0.12 0.477121254719662 12.211145438 NM_198465 V358M 0.12 0.199572354905204 7.019669603 NM_003691 R266W 0.05 1.52287874528034 6.810157213 NM_018979 T674A 0.27 0.160579092877434 6.973095831 NM_018979 A141T 0.10 0.111973759443932 6.973095831 NM_018979 S1506C 0.08 0.229854404540869 6.973095831 NM_018979 D531N 0.01 0.131569315507313 6.973095831 NM_018979 T665I 0.05 0.286789556549371 6.973095831 NM_018979 P1056T 0.64 0.250620492186381 6.973095831 NM_002969 T244M 0.00 0.488116639021126 15.800494596 NM_004203 R140C 0.03 0.350248018334163 11.028636549 NM_174944 Q196R 0.26 0.165625825377516 9.184146922 NM_007118 D348E 0.15 0.45229767099463 9.105397228 NM_007118 A1613T 0.62 0.00616030870481843 9.105397228 NM_007118 E290Q 0.51 0.338818556553381 9.105397228 NM_014264 T232S 0.79 0.581856605239675 9.732544698 NM_003913 P468T 0.54 0.330993219041424 11.617600741 NM_003913 V851F 0.01 1.62586290600059 11.617600741 NM_003913 F754L 0.72 0.0591214521186566 11.617600741 NM_020680 Q59L 0.07 0.059585689984244 9.073403911 NM_020680 S650N 0.26 0.24551266781415 9.073403911 NM_003845 N189S 0.01 0.318758762624413 7.036274256 NM_003845 D454V 0.36 0.0343042311699856 7.036274256 NM_003845 E425Q 0.38 -0.0372480574196294 7.036274256 NM_003845 A61T 0.74 0.0652667315125915 7.036274256 NM_016440 C288Y 0.21 -0.201645363528069 11.223403813 NM_016440 S170P 0.27 -0.47319096109123 11.223403813 NM_016440 S59F 0.01 0.259637310505756 11.223403813 NM_016440 S268L 0.03 0.204119982655925 11.223403813 NM_016440 F171L 1.00 -0.149298082467745 11.223403813 NM_014911 C156G 0.24 1.35001645635485 6.810157213 NM_014911 K509Q 0.42 0.170696227168975 6.810157213 NM_014840 P543R 0.02 -0.0115818725498152 6.810157213 NM_173575 T334A 0.19 0.191225002184738 6.810157213 NM_004217 M298T 0.53 -0.166331421766525 9.732544698 NM_004217 H100Q 0.39 0.182622126214639 9.732544698 NM_004071 N99D 0.57 -0.129959537983351 13.18042733 NM_004071 R465K 0.00 1.61033251729395 13.18042733 NM_004071 E459G 0.05 1.30102999566398 13.18042733 NM_004071 D444N 0.69 0.602059991327962 13.18042733 NM_000297 G449V 0.00 2.73675856522542 0.0938420880000022 NM_000297 I452V 0.58 0.229674087128313 0.0938420880000022 NM_005884 M526I 0.32 1.72699872793626 9.039024567 NM_005884 K442N 0.00 3.85867084720353 9.039024567 NM_004073 S498L 0.65 0.0969100130080564 9.732544698 NM_004073 D491N 0.32 0.525044807036845 9.732544698 NM_004073 L68F 0.01 2.23657200643706 9.732544698 NM_004073 L283F 0.02 0.236572006437063 9.732544698 NM_004073 S618P 0.01 1.30102999566398 9.732544698 NM_004073 R483C 0.03 0.477121254719662 9.732544698 NM_001001852 D143H 0.09 1.10790539730952 6.810157213 NM_014413 E530Q 0.06 0.221848749616356 7.689000378 NM_014413 K558R 0.19 0.451185520625263 7.689000378 NM_006254 F375S 0.00 2.01322826573375 10.103962382 NM_006255 D497Y 0.00 4.04275198042095 7.840715684 NM_006255 V374I 0.37 0.150385858820779 7.840715684 NM_006255 I358T 0.02 0.424092727273526 7.840715684 NM_006256 E94D 0.46 0.282546589969968 8.895884838 NM_014920 P98L 0.01 1.59542941242895 8.861708887 NM_001319 N113K 0.80 0.0746336182969042 7.610548629 NM_021133 R462Q 0.37 0.0621479067488445 9.576815016 NM_021133 R519G 0.10 0.308998925335257 9.576815016 NM_005965 M475I 1.00 0.0377885608893998 6.74154989 NM_005965 Y601C 0.01 0.741721984756969 6.74154989 NM_005965 D520E 0.08 -0.0377885608893998 6.74154989 NM_005965 E471D 0.60 0.755874855672491 6.74154989 NM_005965 L1087H 0.00 3.14976232033333 6.74154989 NM_005965 A253T 0.13 0.0669467896306131 6.74154989 NM_018492 E220D 0.49 -0.0395085412836736 9.958661741 NM_018492 N107S 0.80 0.0180982220927962 9.958661741 NM_005030 N297D 1.00 -0.0347621062592119 14.046431529 NM_005030 F230L 0.21 0.362775591608787 14.046431529 NM_020341 L695F 0.00 0.709070331240344 6.810157213 NM_020341 S403Y 0.01 0.0606978403536116 6.810157213 NM_020341 R335P 0.18 -0.0636690798693773 6.810157213 NM_020341 S341I 0.03 0.158179669746979 6.810157213 NM_020341 S511N 1.00 0.200914842780713 6.810157213 NM_001259 K279R 0.27 0.136582717772008 11.442220679 NM_001259 K279T 0.02 1.45118552062526 11.442220679 NM_001259 K279M 0.03 1.65946146305234 11.442220679 NM_003503 K441R 0.72 0.0579919469776868 17.278597118 NM_003503 G112W 0.00 0.653212513775344 17.278597118 NM_003503 I99V 1.00 0.431798275933005 17.278597118 NM_005109 T304I 0.92 0.111710470874545 9.769540129 NM_005109 A172P 0.24 0.75508594631495 9.769540129 NM_018571 F222I 0.03 0.0669467896306132 7.902278455 NM_001907 T150I 0.09 1.31037002191812 -2.441414415 NM_001907 H173R 0.39 0.0404286570556082 -2.441414415 NM_031417 A601D 0.02 0.130768280269024 14.281056436 NM_031417 E205Q 0.21 0.170890065369874 14.281056436 NM_002497 N354S 0.34 0.264817823009536 13.042377617 NM_005544 G722S 0.39 0.0327925133963075 5.447841548 NM_005544 R854L 0.00 0.204119982655925 5.447841548 NM_005544 M209T 0.12 0.221848749616356 5.447841548 NM_005544 G783R 0.36 -0.130768280269024 5.447841548 NM_005544 G971R 0.14 0.196294645143968 5.447841548 NM_004672 G1233A 0.65 0.131012884320493 6.810157213 NM_004672 S969N 0.40 0.318758762624413 6.810157213 NM_004672 T455I 0.34 0.122717276614342 6.810157213 NM_003948 I132T 0.00 2.47712125471966 11.465919737 NM_001261 A239T 0.52 0.463332970234029 17.013476771 NM_014002 A602V 0.30 0.21867870282685 9.384873935 NM_014002 A371T 0.04 0.209949526316649 9.384873935